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实验性大鼠胃恶性肿瘤的诱发,常由于胃粘膜分泌的粘液形成保护性屏障,而不能使经口进入的致癌剂发生应有的用作 Crant 及 Toshio Takahashi 等曾报导将7,12—二甲基苯蒽(7,12DMBA)包埋于胃壁中,可诱发大鼠(Sprague-Dawley 系)胃腺癌,肉瘤及鳞状上皮癌。甲基苯蒽为一种强烈的致癌物,但其作用常由于甲基的位置不同而结果有很大的差异。9,10二甲基1,2苯蒽对大鼠胃壁的作用如何尚未见实验报导过。作者以此化学药物作大鼠胃壁粘膜外包埋而诱发出了平滑肌肉瘤、恶性间皮瘤及腺棘皮癌。兹简述于后。
The induction of gastric cancer in experimental rats often results from the protective barrier formed by the mucous secreted by the gastric mucosa, and cannot cause oral enter carcinogens to occur as they should be used. Crant and Toshio Takahashi reported that 7,12-II Methylphenylhydrazine (7,12DMBA) is embedded in the stomach and induces gastric (Sprague-Dawley) adenocarcinoma, sarcoma, and squamous cell carcinoma. Methyl benzoquinone is a strong carcinogen, but its effect is often very different due to the difference in the location of the methyl group. The effect of 9,10 dimethyl 1,2 phenylhydrazine on rat stomach wall has not been reported in experiments. The authors used this chemical drug as a submucosa for gastric mucosa in rats to induce leiomyosarcoma, malignant mesothelioma, and adecanosis. It is briefly mentioned later.