曾有作者描术过1例35%红细胞有恶性疟原虫感染的40岁男性病者。昏迷9天,2个月后意识恢复,但情感淡漠,有痉挛性肌紧张,并可能出现严重的永久性神经功能失调。给予奎宁10mg/kg 静滴在4小时内滴完,每8～12小时1次,使血浆奎宁水平达到12～15mg/L的适宜浓度。有其他作者注意到,当奎宁血浆浓度超过10mg/L 时,常常易出现毒性反应,甚至出现永久性眼损害的危险。 One of the authors had a 40-year-old male with 35% erythrocyte-infected P. falciparum. Coma for 9 days, 2 months after the recovery of consciousness, but indifferent emotions, spasmodic muscle tension, and severe permanent neurological disorders may occur. Quinine 10mg / kg intravenous drip completed within 4 hours, once every 8 to 12 hours, the plasma level of quinine to 12 ~ 15mg / L of the appropriate concentration. Other authors have noticed that when quinine plasma concentrations exceed 10 mg / L, toxic reactions are often prone to occur, with the risk of permanent eye damage.