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目的分析并探讨在良性甲状腺结节患者的治疗过程中采用小剂量的左甲状腺素的临床疗效。方法 110例良性甲状腺结节患者作为此次研究对象,随机分为对照组和观察组,各55例,对照组不给予患者任何药物治疗,仅进行随访记录,观察组给予患者小剂量的左甲状腺素进行治疗,比较两组1年后促甲状腺激素、总胆固醇、游离型甲状腺激素、三酰甘油水平,以及两组治疗前后结节直径。结果观察组患者治疗后的促甲状腺激素、总胆固醇以及游离型甲状腺激素的检测结果为(0.32±0.12)m IU/L、(3.74±0.62)mmol/L、(25.91±4.61)pmol/L,均优于对照组患者治疗后的(1.67±0.81)m IU/L、(4.24±0.81)mmol/L、(16.03±3.57)pmol/L,差异具有统计学意义(P<0.05);观察组患者三酰甘油水平(1.35±0.21)mmol/L与对照组(1.37±0.27)mmol/L比较差异无统计学意义(P>0.05)。观察组和对照组患者治疗前结节直径分别为(1.72±0.39)、(1.71±0.38)cm,比较差异无统计学意义(P>0.05);治疗后,观察组患者结节直径为(1.32±0.35)cm,明显小于对照组的(1.67±0.37)cm,差异具有统计学意义(P<0.05)。结论对良性甲状腺结节患者坚持服用小剂量的左甲状腺素进行治疗,能有效的提高患者的临床疗效,抑制患者体内结节的增长和病情的发展,值得推广。
Objective To analyze and discuss the clinical efficacy of low dose of levothyroxine in the treatment of benign thyroid nodules. Methods One hundred and ten patients with benign thyroid nodules were randomly divided into control group and observation group, 55 cases in each group. The control group was given no drug treatment and only the follow-up record was recorded. The observation group was given low dose of left thyroid After treatment, thyrotropin, total cholesterol, free-form thyroid hormone and triglyceride were compared between the two groups after 1 year, and the diameters of nodules before and after treatment were compared between the two groups. Results The levels of thyrotropin, total cholesterol and free thyroid hormone in the observation group were (0.32 ± 0.12) mIU / L, (3.74 ± 0.62) mmol / L, (25.91 ± 4.61) pmol / L, (1.67 ± 0.81) mIU / L, (4.24 ± 0.81) mmol / L and (16.03 ± 3.57) pmol / L after treatment in the control group, the difference was statistically significant (P <0.05); the observation group The level of triglyceride (1.35 ± 0.21) mmol / L was not significantly different from that of the control group (1.37 ± 0.27) mmol / L (P> 0.05). The diameters of the nodules in the observation group and the control group before treatment were (1.72 ± 0.39) and (1.71 ± 0.38) cm, respectively, with no significant difference (P> 0.05). After treatment, the diameter of the nodules in the observation group was (1.32 ± 0.35) cm, which was significantly lower than that of the control group (1.67 ± 0.37) cm, the difference was statistically significant (P <0.05). Conclusions Adhering to taking a small dose of levothyroxine in patients with benign thyroid nodules can effectively improve the clinical efficacy and inhibit the growth of nodules and the development of the disease in patients with thyroid nodules, which is worthy of promotion.