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目的 :探讨阿米卡星药 -时曲线下面积 (AUC)与抗生素后效应 (PAE)的相关性 ,估算阿米卡星体内PAE。方法 :用荧光偏振免疫分析仪 ,检验 7例呼吸道感染患者静脉注射 40 0mg阿米卡星后的血药浓度 ,并计算药代动力学参数 ;以吸收度法测定患者用药后不同时间血中阿米卡星对 6株受试细菌的PAE ,并估算体内累加PAE。结果 :AUC与PAE相关性良好 ,以其回归方程 ,估算阿米卡星体内PAE ,结果阿米卡星对受试标准菌及分离菌体内PAE均较长 ,12h体内累加PAE最大值达 32h左右。结论 :静脉注射 40 0mg阿米卡星后 ,可产生明显的累加体内PAE ,可为该药一日一次给药方案提供药效动力学依据
Objective: To investigate the relationship between amikacin - area under the curve (AUC) and post antibiotic effect (PAE), and to estimate the PAE in amikacin. Methods: Fluorescence polarization immunoassay analyzer was used to test plasma concentration of 40 mg amikacin after intravenous injection in 7 patients with respiratory tract infection, and pharmacokinetic parameters were calculated. Absorbance method was used to determine the plasma concentrations of amikacin MICA star on PAE of 6 tested bacteria, and estimated accumulation of PAE in vivo. Results: The correlation between AUC and PAE was good. The regression equation was used to estimate the PAE in amikacin. The results showed that amikacin had a long PAE to standard bacteria and isolates, and the maximum value of PAE accumulated within 12h was about 32h . CONCLUSIONS: Intravenous injection of 40 mg of amikacin resulted in significant cumulative body PAE, providing a pharmacodynamic basis for its once-daily dosing regimen