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目的 探讨铅锌矿矿区铅镉砷混合接触对不同暴露人群机体免疫状况的影响.方法 选择铅锌矿矿区矿工、矿区居民和无污染地区居民3组人群共96人作为研究对象,对3组人群所处环境中的铅、镉、砷含量,人体血液和尿液的铅、镉、砷含量以及人体免疫学指标进行分析.结果 矿工组血中铅、镉、砷含量几何均数分别为216.57,5.04,58.65μg/L,矿区居民组血中铅、镉、砷含量几何均数分别为143.62,2.42,33.24μg/L,均高于对照人群,几何均数分别为81.54,1.18,11.50μg/L(P<0.01).3组人群尿液中的各种毒物差异有统计学意义(P<0.01).矿工和矿区居民的免疫功能相对于对照组均有不同程度的下降(P<0.01).结论 接触铅、镉和砷的矿区矿工和居民免疫功能受到了不同程度的损害.“,”Objective To study immunological function among the people exposed to lead-cadmium-arsenic mixture in lead-zinc mining area.Methods Miners and inhabitants in mining area and inhabitants in clean area (96 persons) were se-lected as research subjects.The contents of lead,cadmium,and arsenic in the environment,and the immune index and con-tents of lead,cadmium,and arsenic in blood and urine of the subjects were analyzed and compared.Results The geometric mean of lead,cadmium,arsenic in the blood of miners was 216.57,5.04,and 58.65μg/L, respectively; the geometric mean of those elements in the blood of inhabitants of the mining area was 143.62,2.42 and 33.24μg/L,respectively.The means were higher than that of in contrast group (geometric mean: 81.54,1.18, and 11.50μg/L, respectively, P < 0.01).The con-tents of lead, cadmium, and arsenic in the urine among the groups were significantly different(P < 0.01).Compared with the contrast group,the immune function of the miners and the inhabitants in the minming area was decreased (P <0.01).Con-clusion The immune function of the miners and inhabitants in mining area is impaired by lead,cadmium,and arsenic poilu-don.