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恶性肿瘤逃避机体免疫系统的攻击,从而“无限”生长的机制之一是带瘤机体产生的能抑制免疫系统功能的封闭因子的作用.现已证明带瘤宿主血清中的肿瘤特异性封闭因子与某些肿瘤抗体有关,进而证明为IgG,特别是TS Ig和肿瘤抗原-抗体复合物等.如能选择性地除去血浆中的肿瘤特异性封闭因子,必然会增强机体对肿瘤细胞的杀伤作用.Israel用体外血浆交换法,部份除去血浆中的封闭因子,发现血浆交换后,病人的瘤块明显缩小.1974年,Steele根据金黄色葡萄球菌A蛋白可结合多种哺
One of the mechanisms of malignant tumors escaping from the body’s immune system and thus “infinite” growth is the action of the blocking factor produced by the tumor-bearing organism to inhibit the function of the immune system. Tumor-specific closure in tumor-bearing host sera has now been demonstrated. Factors related to certain tumor antibodies, and further proved to be IgG, especially TS Ig and tumor antigen-antibody complexes, etc. Such as selective removal of tumor-specific blocking factor in plasma, will inevitably enhance the body’s killing of tumor cells Effect.Israel used in vitro plasma exchange method to partially remove the blocking factor in plasma and found that after the plasma exchange, the patient’s tumor mass was significantly reduced. In 1974, Steele could combine multiple feeds according to S. aureus A protein.