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目的 :分析食管癌术后复发患者的治疗方法、疗效及其影响因素。方法 :对食管癌胸段鳞癌术后复发的 186例进行回顾性分析。其中复发未治 6 3例 ,单纯放疗 77例 ,单纯化疗 2 5例 ,放疗 +化疗 2 1例。结果 :与未治组比较 ,放疗或合并化疗组复发后生存期较长 ,差异有显著性意义 (P <0 0 5 ) ;单纯化疗组无统计学差异 (P <0 0 1)。COX模型分析显示 :肿瘤浸润深度、淋巴结转移、手术方式及复发后的治疗方式是影响生存率的预后因素。结论 :肿瘤浸润深度和淋巴结转移是影响预后的主要因素 ;提倡颈部吻合术 ;放疗或合并化疗可延长复发患者的生存期 ,更有效的化疗方案有待进一步研究
Objective: To analyze the treatment methods, curative effects and influencing factors of patients with recurrent esophageal cancer. Methods: A retrospective analysis of 186 cases of recurrent thoracic squamous cell carcinoma of the esophagus was performed. Among them, 63 cases had relapsed, 77 cases received radiotherapy alone, 25 cases received chemotherapy alone, and 21 cases received radiotherapy and chemotherapy. Results: Compared with the untreated group, the survival time of recurrence after radiotherapy or chemotherapy group was longer, and the difference was significant (P < 0.05). There was no statistical difference between chemotherapy alone group (P <0 01). COX model analysis showed that the depth of tumor invasion, lymph node metastasis, surgical methods, and post-relapse treatment are prognostic factors that affect survival. Conclusion: The depth of tumor invasion and lymph node metastasis are the main factors affecting the prognosis. The use of neck anastomosis, radiotherapy, or chemotherapy combined with chemotherapy can prolong the survival of relapsed patients. A more effective chemotherapy protocol needs further study.