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纤维结合蛋白(FNT)是一种糖蛋白.在组织修补和止血过程中有广泛而重要的作用,并与凝血系统和血小板功能,特别是与血管内皮细胞的基底膜有密切关系.已知,蜕膜血管内皮的病损、肾小球内皮细胞的增生以及血小板的消耗,常与先兆子痫的临床病理表现同时存在.作者测定孕妇血浆FNT水平,发现先兆子痫患者的值异常升高,认为可作为本病血管内皮细胞损伤的早期标志.15例孕妇分两组,病理组为6例先兆子痫,对照组为9例正常孕妇.前者有持续高血压,伴异常水肿和蛋白尿(>0.3g/日).取血时的孕龄,前者平均为36周(29～41周),后者也是36周(32～40周).用免疫法测定FNT值,试剂取自商用测试箱.
Fibronectin (FNT) is a glycoprotein that has a broad and important role in tissue repair and hemostasis and is closely related to the coagulation system and platelet function, especially to the basement membrane of vascular endothelial cells.It is known, Decidual endothelium lesions, glomerular endothelial cell proliferation and platelet depletion, often associated with the clinical and pathological manifestations of preeclampsia exist.We measured the level of plasma FNT in pregnant women and found abnormal increase in the value of preeclampsia patients, That can be used as early signs of vascular endothelial cell injury in 15 cases of pregnant women in two groups, the pathological group of 6 cases of preeclampsia, the control group of 9 normal pregnant women.The former has persistent hypertension, with abnormal edema and proteinuria > 0.3g / day) .The average gestational age at the time of taking blood was 36 weeks (29-41 weeks) and the latter was 36 weeks (32-40 weeks) .The FNT value was measured by immunoassay and the reagents were taken from the commercial test box.