论文部分内容阅读
目的了解浙江省武义县某敬老院发生戊型病毒性肝炎(戊肝)疫情的原因,并采取控制措施。方法开展问卷调查和病例对照研究。用SPSS 13.0进行数据分析;采集敬老院所有人员88份及相关密切接触者113份血清、猪血清7份、鼠血清4份,用酶联免疫吸附试验检测戊肝抗体(抗-HEV)。结果18份血清标本抗-HEV阳性,猪、鼠血清抗-HEV IgM检测均为阴性。是否喝生水、洗碗后是否用开水冲洗等因素的调查结果,有显著或非常显著的统计学意义[2χ=5.37,Fisher P=0.033,OR=12.4,95%可信区间(CI)1.20~127.75;χ2=14.94,P=0.000,OR=0.084,95%CI0.02~0.35]。临床表现以茶尿、厌食为主,无发热。结论敬老院的戊肝爆发与饮用水污染有关,基本排除食物因素,老年人戊肝临床表现较轻。
Objective To understand the causes of the outbreak of hepatitis E virus in a nursing home in Wuyi County, Zhejiang Province and to take control measures. Methods To carry out questionnaires and case-control studies. SPSS 13.0 was used to analyze the data. In addition, 88 copies of all the staff in the nursing home and 113 related intimate contacts were collected, and seven serum samples were obtained from the swine sera. Four serum samples were obtained from the swine serum. The anti-HEV antibodies were detected by enzyme-linked immunosorbent assay. Results Eighteen serum samples were positive for anti-HEV, but negative for serum anti-HEV IgM in pigs and mice. There was significant or very significant statistical significance for the findings of factors such as whether drinking raw water and washing with water after dishwashing [2χ = 5.37, Fisher P = 0.033, OR = 12.4, 95% confidence interval (CI) 1.20 ~ 127.75; χ2 = 14.94, P = 0.000, OR = 0.084, 95% CI0.02 ~ 0.35]. Clinical manifestations to tea urine, anorexia based, no fever. Conclusion The outbreak of hepatitis E in the nursing home is related to drinking water pollution. The basic elimination of food factors, the clinical manifestations of senile patients with mild hepatitis.