作者回顾了1806例不同炎症病变的皮下组织活检标本,发现其中13个标本有脂膜坏死性改变。13例患者中女12例,男1例,年龄35～70岁,均有腿部炎症性皮肤病史,仅1例累及双臂。胫前呈现结节和结节性斑块。病程4周至15年。大多数病人体重过重。9例有血栓性静脉炎、深部静脉血栓形成或静脉曲张性病史。部分病人伴有结缔组织病、纤维囊性乳腺病、银屑病及慢性溃疡性结肠炎等全身性疾病。组织病理所见:所有病人的深部皮下组织均显示特征性的脂膜病变。后者由不同数量波状起伏增厚的膜所构成,并形成囊腔,囊内衬有增厚的嗜酸性层或平行突起和花纹状透明膜。此种嗜酸性、无核结构形成了乳头状突起从囊壁进入囊内。部分病例中,在其邻近的残存脂肪细胞周围可见类似病 The authors reviewed biopsies of 1806 subcutaneous tissue specimens with different inflammatory lesions and found that 13 specimens had necrotic changes in the lipid membrane. Of the 13 patients, 12 were female, 1 male, aged 35 to 70 years, all had a history of inflammatory skin lesions in the legs, and only 1 had involving both arms. The nodules and nodular plaques are present before the fistula. Duration 4 weeks to 15 years. Most patients are overweight. Nine patients had a history of thrombophlebitis, deep vein thrombosis, or varicose veins. Some patients are associated with systemic diseases such as connective tissue disease, fibrocystic breast disease, psoriasis, and chronic ulcerative colitis. Histopathological findings: Deep subcutaneous tissue of all patients showed characteristic lipid membrane lesions. The latter consists of a variable number of wavy and thickened membranes and forms a sac which is lined with thickened eosinophilic layers or parallel projections and patterned transparent membranes. This eosinophilic, non-nuclear structure formed a papillary protrusion from the cyst wall into the capsule. In some cases, similar diseases can be seen around its neighboring residual fat cells.