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目的:通过分析肿瘤型M2-PK、CEA与CA199在结直肠癌患者中的检测结果,探讨对结直肠癌早期诊断与评判预后的有效检测手段。方法:选择健康体检者30例与结直肠癌患者45例,分析肿瘤型M2-PK、CEA与CA199在健康人群与不同结直肠癌分期(Dukes分期)中的改变,并分析肿瘤型M2-PK、CEA与CA199联合检测在结直肠癌患者中的敏感性、特异性与准确性。结果:以上三项肿瘤血清标志物与结直肠癌的进展呈正相关性(P<0.01),且不同Dukes分期患者与健康人差异具有统计学意义(P<0.05,P<0.01);血清tumor M2-PK检测的敏感性与准确性显著优于另两项指标(P<0.01,P<0.05),三项联合检测的敏感性与准确性则显著优于血清tumor M2-PK(P<0.01,P<0.05)。结论:血清tumor M2-PK、血清CEA和血清CA199检测可作为结直肠癌患者早期诊断与预后评估的有效指标,血清tumor M2-PK的敏感性与准确性优于其他两项指标,而三项联合检测可显著提高敏感性与准确性。
OBJECTIVE: To analyze the detection results of tumor M2-PK, CEA and CA199 in patients with colorectal cancer and to explore the effective detection methods for early diagnosis and prognosis of colorectal cancer. Methods: Thirty patients with healthy subjects and 45 patients with colorectal cancer were selected. The changes of tumor type M2-PK, CEA and CA199 in healthy population and different colorectal cancer stages (Dukes stage) were analyzed. , CEA and CA199 joint detection in patients with colorectal cancer sensitivity, specificity and accuracy. Results: There was a positive correlation between the above three tumor markers and the progress of colorectal cancer (P <0.01), and the difference between Dukes staging and healthy people was statistically significant (P <0.05, P <0.01) The sensitivity and accuracy of -PK detection were significantly better than the other two indicators (P <0.01, P <0.05). The sensitivity and accuracy of the three combined detection were significantly better than that of serum tumor M2-PK (P <0.01, P <0.05). Conclusion: The detection of serum tumor M2-PK, serum CEA and serum CA199 can be used as effective indicators for the early diagnosis and prognosis evaluation of patients with colorectal cancer. The sensitivity and accuracy of serum tumor M2-PK are superior to the other two indicators, while three Joint detection can significantly improve the sensitivity and accuracy.