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目的探讨三维适形调强放射治疗联合TP方案化疗对晚期非小细胞肺癌(NSCLC)的治疗价值。方法选取2008年4月至2012年4月期间收治的60例晚期NSCLC患者作为研究对象,随机分为常规放射治疗组(对照组)和适形调强放射治疗组(试验组),每组30例。放射治疗后定期随访,比较两组患者的疗效和不良反应发生情况。结果试验组患者的有效率为76.7%,中位生存时间为24个月,1年和2年生存率分别为76.4%和43.8%,均较对照组明显提高。治疗期间无致死性不良反应出现。结论适形调强放射治疗联合TP方案化疗治疗NSCLC,不但可以明显增加放射治疗的剂量,提高治疗效果,而且不增加不良反应,具有一定的临床推广价值。
Objective To investigate the therapeutic value of three-dimensional conformal intensity modulated radiation therapy combined with TP regimen in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Sixty patients with advanced NSCLC who were admitted between April 2008 and April 2012 were randomly divided into conventional radiotherapy group (control group) and conformal IMRT group (experimental group), with 30 example. Regular follow-up after radiotherapy, the two groups were compared the efficacy and adverse reactions. Results The effective rate of the trial group was 76.7%, the median survival time was 24 months, and the 1-year and 2-year survival rates were 76.4% and 43.8% respectively, which were significantly higher than those in the control group. No fatal side effects occurred during treatment. Conclusions CRT and TP regimen in the treatment of NSCLC not only can significantly increase the dose of radiation therapy and improve the therapeutic effect, but also does not increase the adverse reaction, and has certain clinical value of popularization.