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目的检测妊娠高压患者血清胱抑素C(Cys-C)、尿微量白蛋白浓度(mAlb)并与血清肌酐、血清尿素氮进行比较,从而评价血清胱抑素、尿微量白蛋白在妊娠高血压患者肾损伤早期诊断中的临床价值。方法应用全自动生化分析仪采用免疫比浊法测定40例妊娠高血压病孕妇和40例正常孕妇的血清Cys-C、BUN、Cr、尿mAlb的浓度,并把妊娠高血压组与正常孕妇组的结果进行比较。结果妊娠高血压组的检测结果为Cys-C(1.41±0.39)、BUN(4.20±1.01)、Cr(61.8±6.62)、mAlb(29.2±7.82),而正常对照组为Cys-C(0.82±0.21)、BUN(4.12±0.98)、Cr(60.3±6.85)、mAlb(7.95±3.66)。Cys-C、mAlb浓度妊娠高血压组较正常对照组的检测结果明显增高,有显著性差异(P<0.01)。结论血清Cys-C、mAlb浓度是一个更为准确,更可靠反映肾小球率过滤功能的指标,Cys-C、mAlb、在反映妊娠高血压早期肾损害比BUN、Cr优越,值得临床上推广应用。
Objective To detect the levels of serum cystatin C (Cys-C) and urine microalbumin (mAlb) in patients with pregnancy-induced hypertension and compare them with serum creatinine and serum urea nitrogen to evaluate the effect of serum cystatin and urinary microalbumin on pregnancy-induced hypertension Clinical value of early diagnosis of renal injury in patients. Methods Serum levels of Cys-C, BUN, Cr and urine mAlb in 40 pregnant women with pregnancy-induced hypertension and 40 normal pregnant women were measured by immunoturbidimetry with automatic biochemical analyzer. The gestational hypertension group and normal pregnant women group The results are compared. Results The levels of Cys-C (1.41 ± 0.39), BUN (4.20 ± 1.01), Cr (61.8 ± 6.62) and mAlb (29.2 ± 7.82) in the gestational hypertension group were significantly higher than those in the normal control group 0.21), BUN (4.12 ± 0.98), Cr (60.3 ± 6.85), mAlb (7.95 ± 3.66). The results of Cys-C and mAlb in pregnancy-induced hypertension group were significantly higher than those in normal control group (P <0.01). Conclusions Serum Cys-C and mAlb concentrations are a more accurate and reliable indicator of glomerular filtration rate. Cys-C and mAlb are superior to BUN and Cr in the early stage of pregnancy-induced hypertension and are worthy of clinical promotion application.