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目的 研究正常人与干燥综合征(Sjogren’s Syndrome,SS)患者球结膜HLA-DR+细胞、朗格罕斯细胞(LC)、T淋巴细胞亚群的变化特征。方法 采用链菌素-过氧化物酶法检测正常人与SS患者球结膜组织。结果 (1)SS患者球结膜大量T淋巴细胞浸润,抑制性T淋巴细胞(CD~(+8))较辅助性T淋巴细胞(CD~(+4))为多。CD~(+4)/CD~(+8)比值升高。(2)SS球结膜中LC数量减少,且鳞状上皮化生明显。(3)SS球结膜中HLA-DR~+细胞较正常人明显增加。结论 SS患者球结膜有显著的病理改变和免疫细胞异常。
Objective To study the changes of the conjunctiva HLA-DR + cells, Langerhans cells (LC) and T lymphocyte subsets in normal and Sjogren’s Syndrome (SS) patients. Methods Streptavidin - peroxidase method was used to detect the conjunctival structure of normal and SS patients. Results (1) There was a large number of infiltration of T lymphocytes in conjunctiva of SS patients. The number of inhibitory T lymphocytes (CD ~ (+8)) was more than that of helper T lymphocytes (CD ~ (+4)). CD ~ (+4) / CD ~ (+8) ratio increased. (2) The number of LC conjunctiva in LC decreased, and squamous metaplasia was obvious. (3) SS bulbar conjunctiva HLA-DR ~ + cells significantly increased compared with normal. Conclusion The conjunctiva of SS patients have obvious pathological changes and abnormal immune cells.