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目的探讨妊娠期肝内胆汁淤积症患者胎儿宫内状况检测及评价的有效方法。方法回顾分析2015年1月-2016年5月在河源市妇幼保健院产科确诊为妊娠期肝内胆汁淤积症孕34~39周患者49例,根据脐血流检测结果 S/D≥3及产前总胆汁酸水平≥40μmol/L分为实验组21例、对照组28例,进行回顾分析。结果实验组胎儿窘迫及新生儿胎粪吸入综合征发生率明显高于对照组,数据分析差异具有统计学意义(P<0.05)。结论脐血流S/D比值结合总胆汁酸水平检测为妊娠期胆汁淤积症患者胎儿宫内状况检测较为敏感的指标,对于适时终止妊娠具有指导意义。
Objective To investigate the detection and evaluation of intrauterine fetal status in patients with intrahepatic cholestasis of pregnancy. Methods From January 2015 to May 2016, 49 cases of 34-39 weeks pregnant women with intrahepatic cholestasis of pregnancy were diagnosed in Maternity and Child Health Care Hospital of Heyuan City from January 2015 to May 2016. According to the results of S / D≥3 and cord blood flow test Former total bile acid levels ≥40μmol / L were divided into experimental group 21 cases, control group 28 cases, for retrospective analysis. Results The incidence of fetal distress and neonatal meconium aspiration syndrome in the experimental group was significantly higher than that in the control group, with statistical significance (P <0.05). Conclusion The S / D ratio of umbilical cord blood and total bile acid level is a sensitive index for detection of intrauterine fetal status in patients with cholestasis of pregnancy. It is instructive to terminate the pregnancy timely.