【摘 要】
:
The neuromuscular junction (NMJ),a peripheral synaptic connection between motoneurons and skeletal muscle fibers,controls movement.Dysregulation of NMJs has been implicated in various motor disorders.Because of their large size and easy accessibil-ity,NMJ
【机 构】
:
Department of Neurobiology,The First Affiliated Hospital,Institute of Translational Medicine,School
论文部分内容阅读
The neuromuscular junction (NMJ),a peripheral synaptic connection between motoneurons and skeletal muscle fibers,controls movement.Dysregulation of NMJs has been implicated in various motor disorders.Because of their large size and easy accessibil-ity,NMJs have been extensively investigated in the neuroscience field and have greatly contributed to our understanding of the fundamental principles of synapses in the central nervous system.Researchers have tried multiple ways to develop models to recreate NMJs.Rapid progress in the research and development of tissue-like organoids has made it possible to produce human NMJ three-dimensional (3D) models in vitro,providing an additional powerful strategy to study NMJs.Here,we introduce the most recent advances of human embryonic stem cell-or induced pluripotent stem cell-derived organoids to model 3D NMJs.
其他文献
Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium.For blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate
The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2)has presented some neurological manifestations including hyposmia,hypogeusia,headache,stroke,encephalitis,Guillain-Barre syndrome,
The coronavirus diseases 2019 (COVID-19) caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 has caused more than 140 million infections worldwide by the end of April 2021.As an envel-oped singl
乡村治理是国家治理的重要基础,是实现国家治理体系和治理能力现代化建设的基层工程.少数民族地区传统文化的现代价值重塑,是推进基层治理体系,完善基层治理机制的内在需要.桂西南壮族地区传统文化与乡村治理的多维耦合空间,表征出“文化空间”“空间表征”“象征秩序”三个维度的空间生产特性.在新时代“共建共治共享”社会治理制度,“自治法治德治”结合的基层治理体系中,乡村治理中的个体实践能动性、内在价值动能性和社会互动礼俗性,诠释出了地方传统在乡村治理中的价值重塑效能.
The centrosome is a membrane-less organelle consisting of a pair of barrel-shaped centrioles and pericentriolar material and functions as the major microtubule-organizing center and signaling hub in animal cells.The past decades have witnessed the functio
Macroautophagy (hereafter referred to as autophagy) is a conserved eukaryotic process,in which dysfunctional pro-teins,organelles,and other macromole-cules are wrapped in intracellular vesicles called autophagosomes and de-livered to lysosomes for degrada
史学是否是科学,是史学史的百年论题.文艺复兴使史学摆脱经院束缚,转向“人”的研究.启蒙哲学推导人类社会规则,史学冠以理性主义与科学性.19世纪历史主义方法论提倡档案考据,主张历史具体而非普适性.20世纪之际史学借鉴社会科学方法论,趋于科学化.后现代承继人文主义,赋予史学主观性与叙事质性.后现代之后,史学界正视史学的社会科学属性,肯定其真实性、客观性和规律性.如同现代国家与理性主义、科学主义合流,形成社会科学诞生的历史基础;后现代后之失序与重建,促使哲学、人类学、历史本体论回归,亦使社会科学史学研究回归.
针对滚动轴承退化信号的非平稳、非线性特点以及全寿命退化状态难以有效识别的问题,提出一种基于变分模态分解(VMD)和长短时记忆神经网络(LSTM)相结合的滚动轴承退化状态识别方法.该方法首先采用麻雀搜索算法(SSA)对VMD的两个参数(模态分量个数和惩罚因子)进行优化;然后将滚动轴承振动信号分解成若干个本征模态函数(IMF),再根据皮尔逊相关系数选择VMD分解得到的敏感IMF分量,对其 重构后进行特征提取;最后将多维退化特征输入LSTM模型训练,建立退化状态模型.实验结果表明该方法能够准确识别轴承的退化状态
“团结”存在动词与形容词的属性差异,现代以形容词义为主的“民族团结”以平等为前提,径由中国历部宪法不断发展完善.《宪法》第52条民族团结义务是新时代民族工作法治化的核心规范,对其宪法内涵,应从第52条自身及其分别与序言和总纲第4条的关系共三个层次梯度诠释;对其外延的解读则可从中央和地方两个层次的法制体系入手.民族团结作为基本义务进入宪法文本,有其坚实的理论、逻辑和渊源基础,其内涵明确、规范谱系定位清晰、实施机制完善.当前,应促进民族团结政策话语的法治转向,做好理论和实践双重准备,适时启动《民族团结进步条例
三江源生态移民家长教育参与过程受主客观多重因素的影响.基于生境理论从生态移民家长的教育参与意识、参与能力与参与行为三个维度的现实困境进行分析.通过对该地的调查研究发现,生计方式、文化不适及知识和价值观的断层是导致当前生态移民家长教育参与意愿淡泊、参与能力不足与参与行为被动的主要原因.为此,应充分发挥网络媒介平台作用,加强生态移民家长教育参与意识;遵循“他者性”的教育理论,弥补生态移民家长教育参与能力;完善政策制定和法律规范,规范生态移民家长教育参与行为.以破解三江源生态移民家长教育参与的困境,为促进三江源