肺泡蛋白沉着症是一种罕见的疾病,1958年由Rosen等首先描述。它有各种各样的临床表现,从毫无临床症状到急性呼吸衰竭,并可伴随恶性血液病和矽肺,合并不常见的病原体感染,特别是奴卡氏放线菌。本文报道的13例,均经肺活检证实,其中合并肺部感染2例,矽肺2例,其它肺部疾病3例。 Alveolar proteinosis is a rare condition that was first described by Rosen et al. In 1958. It has a wide range of clinical manifestations ranging from no clinical signs to acute respiratory failure and can be associated with hematologic malignancies and silicosis, with less common pathogen infections, particularly Actinobacillus nodosum. In this paper, 13 cases were confirmed by biopsy, including 2 cases of pulmonary infection, 2 cases of silicosis and 3 cases of other lung diseases.