冠心病易感基因MEF2A的转录产物MEF2A蛋白是一类脱氧核糖核酸(DNA)结合蛋白,其在功能上有许多独特点。它们与基因启动子中特定序列结合,从而调节基因的表达。近年来的研究表明,转录因子MEF2A在血管平滑肌细胞(MSMC)的增殖及内皮细胞的发育、功能和结构维持中起重要调控作用[1] MEF2A, a transcriptional product of the coronary heart disease susceptibility gene MEF2A, is a type of DNA-binding protein that has many unique features. They bind to specific sequences in the promoter of the gene, thereby regulating gene expression. Recent studies have shown that transcription factor MEF2A plays an important regulatory role in the proliferation of vascular smooth muscle cells (MSMCs) and the development, function and structure of endothelial cells [1]