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目的探讨疏肝解郁胶囊联合兰索拉唑和莫沙必利治疗伴有抑郁焦虑状态的功能性消化不良的临床效果。方法选取2012年12月—2014年6月106例伴抑郁焦虑状态的功能性消化不良患者为研究对象,随机分成2组,对照组53例,予联合兰索拉唑和莫沙必利;观察组53例,在对照组的基础上加用疏肝解郁胶囊治疗,观察治疗后疗效、不良反应等指标变化情况。结果疗效上,对照组痊愈率为24.53%、总有效率为79.25%,观察组痊愈率为39.62%、总有效率为94.34%,观察组在痊愈率和总有效率上显著优于对照组(P<0.05);两组治疗后在抑郁、焦虑评分上均较治疗前显著下降,治疗前后比较差异显著(P<0.05),治疗后观察组抑郁、焦虑评分显著优于对照组(P<0.05);两组治疗后NOS较治疗前显著下降,5-HT较治疗前显著升高,治疗前后比较差异显著(P<0.05),治疗后观察组5-HT、NOS显著优于对照组(P<0.05);对照组睡眠障碍、头晕、便秘等不良反应发生率为58.49%,观察组睡眠障碍、头晕、便秘等不良反应发生率为20.75%,观察组显著低于对照组,两组比较差异显著(P<0.05)。结论疏肝解郁胶囊联合兰索拉唑和莫沙必利治疗伴有抑郁焦虑状态的功能性消化不良临床疗效满意。
Objective To explore the clinical effects of Shugan Jieyu capsule combined with lansoprazole and mosapride on functional dyspepsia with depression and anxiety. Methods A total of 106 patients with functional dyspepsia with depression and anxiety from December 2012 to June 2014 were randomly divided into 2 groups and 53 in the control group. The patients were treated with lansoprazole and mosapride. Group 53 cases, in the control group based on the use of Shugan Jieyu capsule treatment, observed after treatment efficacy, adverse reactions and other indicators changes. Results The cure rate in the control group was 24.53%, the total effective rate was 79.25%. The cure rate in the observation group was 39.62%, the total effective rate was 94.34%. The cure rate and total effective rate in the observation group were significantly better than those in the control group P <0.05). After treatment, depression and anxiety scores decreased significantly in both groups before and after treatment (P <0.05). After treatment, depression and anxiety scores in observation group were significantly better than those in control group (P <0.05) (P <0.05). After treatment, the 5-HT and NOS in the observation group were significantly better than those in the control group (P <0.05) <0.05). The incidence of adverse reactions such as sleep disorders, dizziness and constipation in the control group was 58.49%. The incidence of adverse reactions such as sleep disorders, dizziness and constipation in the observation group was 20.75%, which was significantly lower in the observation group than in the control group Significant (P <0.05). Conclusion Shugan Jieyu capsule combined with lansoprazole and mosapride treatment of functional dyspepsia associated with depression and anxiety clinical efficacy is satisfactory.