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Angew.Chem.Int.Ed.2012,51,780~783手性α-季碳羟基酸及α-季碳羟基酮是有机合成和药物合成中非常有用的分子,它们的骨架结构广泛存在于天然产物分子和生物活性分子中,由于分子中的手性季碳结构,如何高效构建它们一直是有机合成中一个很具挑战性的课题.中国科学院上海药物研究所徐明华等以课题组新近发展的结构极其简单的直链线形小分子硫烯化合物(仅两步简单反应“一锅”合成,Org.Biomol.Chem.2012,10,1764~1768,封面文章)为新型手性配体,成功实现了各种芳
Angew. Chem. Int. Ed. 2012, 51, 780-783 Chiral α-quaternary carbolic acids and α-quaternary hydroxyketones are very useful molecules in organic synthesis and drug synthesis. Their skeletal structures are widely found in natural product molecules And bioactive molecules, how to efficiently construct them due to the chiral quaternary carbon structure in the molecule has always been a very challenging issue in organic synthesis. The newly developed structure of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Xu Minghua and others is extremely simple (A simple two-step reaction “one-pot” synthesis, Org. Biomol. Chem. 2012, 10, 1764-1768, cover article) was successfully used as a novel chiral ligand A variety of aromatic