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细胞因子是由免疫细胞(单核巨噬细胞、T淋巴细胞、B淋巴细胞及NK细胞)及相关细胞(如血管内皮细胞、纤维母细胞等)产生的一类可调节细胞功能的高活性、多功能的多肽分子。在病理状态下,细胞因子在介导和调节自身免疫性疾病、慢性炎症、肿瘤及HIV感染中具有重要作用。细胞因子具有双重效应,既可抵御和治疗某些疾病,也可能导致和促进某些疾病的发生。细胞因子调节疗法有补充/添加疗法和阻断/拮抗疗法两类。早期细胞因子阻断/拮抗疗法是被动免疫抗细胞因子抗体,但此种疗法存在明显的缺陷和不足。主动免疫疫苗可激发体内产生自身细胞因子抗体,阻断细胞因子活性,是近年来细胞因子调节疗法的主要进展之一,本文对此领域的研究进展作一综述。
Cytokines are a type of high-activity, cell-mediated, cytokines that are produced by immune cells (mononuclear macrophages, T lymphocytes, B lymphocytes and NK cells) and related cells (such as vascular endothelial cells and fibroblasts) Multifunctional peptide molecules. Under pathological conditions, cytokines play an important role in mediating and regulating autoimmune diseases, chronic inflammation, tumors and HIV infection. Cytokines have a dual effect, both to resist and treat certain diseases, may also lead to and promote the occurrence of certain diseases. Cytokine-modulating therapies are complementary / additive and blockade / antagonistic. Early cytokine blockade / antagonist therapy is a passive immunization of anti-cytokine antibodies, but this therapy has obvious shortcomings and deficiencies. Active immunization vaccine can stimulate the body to produce their own cytokine antibodies, blocking cytokine activity is cytokine regulation therapy in recent years, one of the major advances in this paper, the research progress in this field are reviewed.