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选择健康雄性Ｗｉｓｔａｒ大鼠４０只，随机分为５组，观察氟对大鼠红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性的影响及“抗氟灵”的拮抗作用。染毒及给药方式为自由饮式，染毒剂量为１８０ｍｇＦ－／Ｌ“抗氟灵浓度为２４ｇ％；染毒时间为２个月，“抗氟灵”治疗时间为１个半月。结果显示，染氟组动物红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性均有显著升高，给予氟＋“抗氟灵”组比染氟组显著降低；氟中毒后给予“抗氟灵”治疗组明显低于治疗对照组。提示氟对红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ活性有促进作用，而“抗氟灵”具有拮抗氟的作用
Forty healthy male Wistar rats were randomly divided into five groups. The effects of fluoride on the activity of Na + -K + -ATPase and Ca2 + -ATPase in rat erythrocyte membrane and the antagonism of “Fuling” were observed. Toxicity and mode of administration for the free drink, the dose of 180mgF- / L “antifluralin concentration of 24g%; exposure time of 2 months,” anti-fluoride Ling “treatment time was 1 and a half months. , Fluoride-exposed animals erythrocyte membrane Na + -K + -ATPase, Ca2 + -ATPase activity were significantly increased, given fluorine + ”anti-fluoride Ling“ group significantly lower than the fluoride group; fluoride poisoning after ”anti-fluoride“ treatment group Which was significantly lower than that of the control group, suggesting that fluorine could promote the activity of Na + -K + -ATPase and Ca2 + -ATPase in erythrocyte membranes, while ”Fluorin" could antagonize the action of fluoride