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目的:观察针刺对高脂血症小鼠的疗效及作用机制.方法:将雄性清洁级昆明小鼠120只,随机分为正常组、模型组各40只,针刺组和药物组各20只.除正常组外采用高脂饮食饲料喂养制备高脂血症小鼠模型.造模第15天检测正常及造模动物各20只的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇( LDL-C)、高密度脂蛋白胆固醇(HDL-C)；同时针刺组开始电针双侧“丰隆”“曲池”“三阴交”穴10 min,每日1次,连续干预10 d；药物组灌服辛伐他汀,每日1次,连续10 d.治疗结束后检测各组血清TC、TG、LDL-C、HDL-C及丙二醛(MDA)、一氧化氮(NO)、内皮素(ET)含量和超氧化物歧化酶( SOD)活力.结果:第15天,模型组小鼠血清TG、TC、LDL-C含量均高于正常组(P＜0.05),HDL-C含量低于正常组(P＜0.01).治疗10 d后,针刺组、药物组小鼠血清TG、TC、LDL-C以及MDA、ET含量均低于模型组,血清HDL-C、NO含量以及SOD活力高于模型组(P＜0.05,P＜0.01),且针刺组的改善作用优于药物组(P＜0.05,P＜0.01).结论:针刺治疗能够调节高脂血症小鼠血脂代谢,抵抗脂质过氧化,并具有保护血管内皮功能的作用.“,”Objective To observe therapeutic effects of acupuncture on the mouse of hyperlipemia and to explore the mechanisms.Methods One hundred and twenty Kunming mice,male,sanitary degree,were randomly divided into normal group (n=40),a model group (n=40),an acupuncture group (n=20) and a medicine group (n=20).Except the normal group,the mice were fed with high fat forage to prepare mouse hyperlipemia model.On the 15th day of modeling,serum total cholesterol (TC),triglyceride (TG),low density lipoproteincholesterol (LDL-C),high density lipoprotein-cholesterol (HDL-C) levels were detected in 20 normal mice and 20 model mice; electroacupuncture was given at bilateral “Fēnglóng” (丰隆 ST 40),“Qūchí” (曲池 LI 11),“Sānyīnjiāo” (三阴交 SP 6) in the acupuncture group,once a day,for 10 consecutive days; in the medicine group,the mice were intragastrically administrated with Simvastatin,once daily,for 10 consecutive days.After the end of treatment,serum TC,TG,LDL-C,HDL-C,malondialdehyde (MDA),nitric oxide (NO) and endothelin (ET) contents and superoxide dismutase (SOD) activities were detected in the groups.Results On the 15th day of modeling,in the model group serum TG,TC,LDL-C contents were significantly higher (all P＜0.05) and HDL-C content was significantly lower (P＜0.01) than those in the normal group.After treatment for 10 days,in the acupuncture group and the medicine group serum TG,TC,LDL-C,MDA and ET contents were significantly lower and serum HDL-C and NO contents and SOD activities were significantly higher than those in the model group (P＜0.05,P＜0.01),and the improving action in the acupuncture group was better than that in the medicine group (P＜0.05,P＜0.01).Conclusion Acupuncture can regulate fat metabolism,resist lipid peroxidation and protect vascular endothelial function in the mouse of hyperlipemia.