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目的探讨糖尿病肾病（ＤＮ）病人２４ｈ尿液特定蛋白变化的意义。②方法采用免疫速率散射比浊法，检测了１２６例２型糖尿病（ＤＭ）病人和１１８例正常人的２４ｈ尿液清蛋白排泄率（ＵＡＥ），α１－微球蛋白（α１－Ｍ），β２－微球蛋白（β２－Ｍ），转铁蛋白（ＴＲＦ），免疫球蛋白Ｇ（ＩｇＧ）的变化。③结果ＤＭ病人、无ＤＮ病人、早期ＤＮ病人、临床ＤＮ病人的ＵＡＥ，α１－Ｍ，ＴＲＦ和ＩｇＧ明显高于对照组，差异有显著性（ｔ＝３．０３～８９．８５，Ｐ＜０．０１），而无ＤＮ和早期ＤＮ病人的β２－Ｍ与对照组比较差异无显著性（ｔ＝１．１６，１．５１，Ｐ＞０．０５）。ＤＮ病人较无ＤＮ组上述指标明显升高（ｔ＝１１．０２～５２．４８，Ｐ＜０．０１），临床ＤＮ组较早期ＤＮ组上述指标明显升高（ｔ＝５．８７～１９．４５，Ｐ＜０．０１）。ＤＮ病人的α１－Ｍ，ＴＲＦ，ＩｇＧ与ＵＡＥ呈正相关（ｒ＝０．５４７～０，９６４，Ｐ＜０．０１），而β２－Ｍ与ＵＡＥ无相关性（ｒ＝０．０３６，Ｐ＞０．０５）。④结论ＵＡＥ，α１－Ｍ，ＴＲＦ，ＩｇＧ对ＤＮ的早期诊断有重要意义，而β２－Ｍ对早期ＤＮ诊断无价值。
Objective To investigate the significance of 24-hour urine specific protein in patients with diabetic nephropathy (DN). Methods The urinary albumin excretion rate (UAE), α1-microglobulin (α1-M) and β2 in 126 type 2 diabetic patients and 118 normal persons were detected by immunostaining nephelometry. - Microglobulin (β2-M), transferrin (TRF), immunoglobulin G (IgG) changes. Results The levels of UAE, α1-M, TRF and IgG in DM patients, DN patients, early DN patients and clinical DN patients were significantly higher than those in control group (t = 3.03 ~ 89.85, P <0 .01). There was no significant difference of β2-M between DN patients without DN and early DN patients (t = 1.16,1.51, P> 0.05). The above indexes of DN patients were significantly higher than those of no DN group (t = 11.02 ~ 52.48, P <0.01). The above indexes in DN group were significantly higher than those in DN group (t = 5.87-19). 45, P <0.01). There was a positive correlation between α1-M, TRF, IgG and UAE in patients with DN (r = 0.547-0.964, P <0.01), but there was no correlation between β2- 0.05). ④ Conclusion UAE, α1-M, TRF and IgG are of great significance in the early diagnosis of DN, while β2-M is of no value in the diagnosis of early DN.