对重组人碱性成纤维细胞生长因子（ｒｈ－ｂＦＧＦ）毒性试验恒河猴的舌象及舌的病理组织学进行了观察，结果：高剂量组变化明显，舌背及舌腹面粘膜稍晦暗，舌质略欠红活，无舌脉粗张及细络瘀血；镜下见舌背、舌腹面粘膜固有层及下层淋巴细胞浸润、滤泡样结构形成，毛细血管、小动脉内皮细胞增生肥大，小动脉壁增厚，结构不清，丝状乳头粘膜细胞局灶性胞浆内出现嗜酸性颗粒。认为是ｒｈ－ｂＦＧＦ促内皮细胞增殖功能与免疫反应原体现 The pathological histology of tongue and tongue of rhesus monkeys were observed in rh-bFGF toxicity test. Results: The high dose group changed obviously, the tongue back and lingual mucosa slightly dull, Tongue slightly less red live, no tongue veins and thin network bruising; see the tongue back, tongue ventral mucosal lamina propria and lower lymphocyte infiltration, follicular structure formation, capillaries, arteriolar endothelial cell hyperplasia , Arteriolar wall thickening, unclear structure, filamentous papillary mucosa cells appear in the cytoplasm eosinophilic granules. It is considered that rh-bFGF promote endothelial cell proliferation and immune response