作为一层选择性半透膜,内皮细胞通过细胞间以及细胞与基质的相互作用,构成物质交换的屏障,不仅为血流提供光滑的表面,还参与许多生理调节,包括免疫反应、血管生成及组织体液的稳态。内皮细胞受损导致屏障功能下降将导致疾病的发生,如蛋白渗出肺间质引起肺水肿和肺部急性损伤等[1]。而非受体型酪氨酸蛋白激酶(Src)是最早发现的蛋白质酪氨酸磷酸激酶之一,在细胞内信号转导 As a selective semipermeable membrane, endothelial cells act as a barrier to material exchange through intercellular and cell-matrix interactions, providing not only a smooth surface for blood flow, but also many physiological regulators including immune responses, angiogenesis and Body fluid steady state. Damage caused by endothelial cells lead to decreased barrier function will lead to the occurrence of diseases such as protein exudation interstitial pulmonary edema caused pulmonary and acute lung injury [1]. Non-receptor tyrosine kinase (Src) is one of the earliest found protein tyrosine phosphatase, in intracellular signal transduction