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对44名西双版纳傣族和9名上海地区汉族DK2阳性个体进行了与其相关的DR/DQ单倍型组合的分析。傣族群体中DRBI-DR2亚型分布以*1602与*1502为最常见,其等位基因频率分别为43.6%与,40.0%和汉族群体中以*1501为主明显不同。傣族群体中共检出10种与DR2相关联的DR/DQ单倍型;最常见的是DRB1*1602、DRB5*0101、DQA1*0102、DQB1*0502(34.5%)与汉族及其他群体明显不同,本研究表明傣族不仅具有高频率的DR2,而且与DR2相关联的DRB1、DRB5、DQA1、DQB1单倍型组合有其独特性。
The association of DR / DQ haplotypes was analyzed in 44 Xikangbanna Dai nationality and 9 Shanghai Han DK2 positive individuals. The distribution of DRBI-DR2 subtypes in Dai population was the most common with * 162 and * 1502 alleles, and the allele frequencies were 43.6% and 40.0%, respectively, and were significantly different from those in the Han population . There were 10 DR / DQ haplotypes associated with DR2 detected in the Dai population. The most common were DRB1 * 1602, DRB5 * 0101, DQA1 * 0102, DQB1 * 0502 (34.5%) and Han This study shows that Dai people not only have high frequency of DR2, but also have the uniqueness of DRB1, DRB5, DQA1 and DQB1 haplotype combinations associated with DR2.