【摘 要】
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Interleukin 12 (IL-12) and/or interleukin 18 (IL-18) gene ablated mice were applied for the investigation of the tissue expression of interferon γ (IFN-γ). Fo
【机 构】
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School of Life Sciences,Laboratory Animal Center
论文部分内容阅读
Interleukin 12 (IL-12) and/or interleukin 18 (IL-18) gene ablated mice were applied for the investigation of the tissue expression of interferon γ (IFN-γ). For IL-12-/-, IL-18-/-, IL-12-/-/18-/- and wt mice, reproductive performance were recorded and IFN-γ concentrations in heart, lung, liver, spleen, kidney and serum were quantified by ELISA.There were no significant differences of IFN-γ in heart, lung and kidney between 4 strains although control group was higher. It was observed that for IL-12-/- mice, compared with other 3 groups, IFN-γ in liver and spleen were decreased (p ＜ 0.05) and reproductive performance appeared to be impaired. Serum IFN-γ level of IL-12-/-/18-/-mice was significantly higher (p ＜ 0.05). It was showed that IFN-γ productions under the normal condition were independent upon IL-12 and IL-18, its expressions in various tissues were different, and optimal IFN-y is necessary for the normal growth and development of mammals. This study is helpful for clinical cytokines therapy.
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