In recent years big strides have been made in the exploration of ores in the central-south segment of the Da Hinggan Ling Range,though some debates still exist on the metallogenesis and sources of ore-forming materials.Pyrite and other sulfides in direct relation to the Pb-Zn-Ag ore deposits were chosen for the He and Ar isotopic analysis of ore-forming fluids,and the first He and Ar isotope data have been obtained from the study region.3He/4He ratios in 14 samples collected from 7 mining districts are 2.17×10-6-12.52×10-6,averaging 6.86×10-6 and their R/Ra ratios are 1.56-9.01 Ra,averaging 4.37 Ra.By projecting the data points onto the 3He-4He concentrations diagram,all the points fall near the mantle helium area.The calculated mantle-source helium ratios are within the range of 19.58%-76.96%,with an average of 49.52%.Argon isotopic characteristics are close to those of mantle source,indicating that the ore-forming material was transport upwards via the multi-stage evolution of mantle plume and concentrated as ores in the favorable loci of mantle branch structures. In recent years big strides have been made in the exploration of ores in the central-south segment of the Da Hinggan Ling Range, though some debates still exist on the metallogenesis and sources of ore-forming materials. Pyrite and other sulfides in direct relation to the Pb-Zn-Ag ore deposits were chosen for the He and Ar isotopic analysis of ore-forming fluids, and the first He and Ar isotope data have been obtained from the study region. 3He / 4He ratios in 14 samples collected from 7 mining districts are 2.17 × 10-6-12.52 × 10-6, averaging 6.86 × 10-6 and their R / Ra ratios are 1.56-9.01 Ra, averaging 4.37 Ra. By projecting the data points onto the 3He-4He concentrations diagram, all the points fall near the mantle helium area. The calculated mantle-source helium ratios are within the range of 19.58% -76.96%, with an average of 49.52%. Argon isotopic characteristics are close to those of mantle sources, indicating that the ore- forming material was transport upwards via the multi-stage evolution of man tle plume and concentrated as ores in the favorable loci of mantle branch structures.