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目的:观察平积汤对子宫肌瘤患者宫内膜中雌孕激素受体(ER、PR)表达的影响。方法:平积汤方治疗子宫肌瘤3个月,对照组服用大黄蛰虫丸。分别于治疗前后经行期抽取子宫内膜,采用SP免疫组化染色法以分级定量标准,测定子宫内膜中ER、PR含量的变化。结果:治疗后两组子宫内膜中ER、PR水平均有降低,提示:两组治疗后比较统计学差异有显著性(P<0.05)。结论:平积汤方可通过抑制ER、PR表达来控制肌瘤生长。
Objective: To observe the effect of Pingji Tang on the expression of estrogen, progesterone receptor (ER, PR) in endometrium of uterine leiomyoma patients. Methods: Flat plot soup for the treatment of uterine fibroids 3 months, the control group taking rhubarb worms pills. The endometrium was taken before and after treatment, and the levels of ER and PR in the endometrium were determined by SP immunohistochemical staining. Results: The levels of ER and PR in the two groups of endometrium decreased after treatment, suggesting that there was a significant difference between the two groups after treatment (P <0.05). Conclusion: Pingji Tang can inhibit the growth of fibroids by inhibiting the expression of ER and PR.