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60年代从精囊中大量提取、精制并确定前列腺素(PG)至少有六种不同的化学结构——PGE_1、E_2、E_3、F_1α、F_2α、F_3α。后来分别由Hanberg(1975)及Moncade(1976)发现了血栓烷素A_2(Thromboxane _2、简称TXA_2)及前列腺环素(PGI_2)。各方面研究表明,由花生四烯酸加氧合成PGH_2,后者转化成TXA_2及PHI_2,TXA_2和PGI_2在多个系统和多种疾病的病理生理过程中有相反作用。现就PGE、PGI_2及TXA_2、PGF_1α对肝脏和肝脏疾病的作用,扼要予以介绍。前列腺素(PGE)与肝脏
In the 1960s, a large number of PGs were extracted from the seminal vesicles and refined to determine PGs with at least six different chemical structures - PGE_1, E_2, E_3, F_1α, F_2α, F_3α. Later, Hanberg (1975) and Moncade (1976) found thromboxane A_2 (TXA_2) and prostacyclin (PGI_2). Various studies have shown that the synthesis of PGH_2 from arachidonic acid by oxygenation transforms into TXA_2 and PHI_2, and TXA_2 and PGI_2 have opposite effects in the pathophysiology of multiple systems and diseases. Now PGE, PGI_2 and TXA_2, PGF_1α on liver and liver disease, briefly introduced. Prostaglandin (PGE) and liver