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目的观察ＰＣＮＡ、ＥＧＦＲ和ｃ－ｅｒｂＢ２基因蛋白在宫颈鳞状上皮癌中的表达，探讨其意义。方法对４５例宫颈鳞状细胞癌进行免疫酶标记，并设２０例宫颈慢性炎标本作对照。结果正常鳞状上皮仅少数基底细胞表达ＰＣＮＡ、ＥＧＦＲ和ｃ－ｅｒｂＢ２呈可忽略的弱阳性；在鳞状上皮癌组织中ＰＣＮＡ表达明显高于正常及化生的鳞状上皮且和细胞分化呈显著负相关，２５／４５例、１３／４５例分别过度表达ＥＧＦＲ、ｃ－ｅｒｂＢ２蛋白。结论ＰＣＮＡ、ＥＧＦＲ、ｃ－ｅｒｂＢ２蛋白的表达在判断良恶性病变、肿瘤的恶性程度推测其预后具有一定的价值，特别是对活检标本进行标记可为临床选择进一步治疗的方法提供依据。
Objective To observe the expression of PCNA, EGFR and c-erbB2 in cervical squamous cell carcinoma and to explore its significance. Methods 45 cases of cervical squamous cell carcinoma were immunostained and 20 cases of chronic cervicitis were used as control. Results In normal squamous epithelium, PCNA expression was only found in a few basal cells, and EGFR and c-erbB2 were negligible. In squamous cell carcinoma, the expression of PCNA was significantly higher than that in normal and metaplastic squamous epithelium and the cell differentiation was significant Negative, 25/45 cases, 13/45 cases overexpression of EGFR, c-erbB2 protein. Conclusions The expressions of PCNA, EGFR and c-erbB2 protein are valuable in predicting benign and malignant lesions and predicting the malignant degree of the tumor. Especially, biopsy specimens can be used as a basis for further clinical treatment.