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目的分析血清内脂素在2型糖尿病及其合并冠心病中的变化,并探讨内脂素与糖尿病或/和冠心病的相关关系。方法依据WHO的糖尿病诊断标准随机选择2型糖尿病(T2DM)患者61例,经心电图及冠脉造影检查分为:单纯T2DM组(DM)18例、T2DM合并冠心病(CHD)组(DC)43例以及正常对照组(NC)29例,其中DM组均为新诊断患者。经统计学分析3组间一般资料具有可比性。结果DM组及DC组血清内脂素浓度水平显著高于健康人对照组(t=4.992 1,P<0.05;t=4.722,P<0.05)。DC组患者血清内脂素水平与DM组对照组有显著下降(t=4.236,P<0.05)。结论2型糖尿病患者内脂素水平下降可能提示冠心病的发生或加重,在2型糖尿病合并冠心病诊断和治疗中可能具有一定的意义。
Objective To analyze the changes of serum visfatin in type 2 diabetes mellitus and its combined coronary heart disease and to explore the correlation between visfatin and diabetes and / or coronary heart disease. Methods Sixty-one patients with type 2 diabetes mellitus (T2DM) were randomly selected according to the diagnostic criteria of WHO diabetes. The electrocardiogram and coronary angiography were divided into two groups: 18 cases with T2DM alone, and 20 cases with T2DM complicated with coronary heart disease (CHD) 43 Cases and normal control group (NC) 29 cases, including DM group were newly diagnosed patients. The statistical analysis of the general information between the three groups is comparable. Results Serum visfatin levels in DM group and DC group were significantly higher than those in healthy controls (t = 4.992 1, P <0.05; t = 4.722, P <0.05). Serum visfatin levels in patients with DC were significantly lower than those in DM patients (t = 4.236, P <0.05). Conclusions The decline of visfatin level in patients with type 2 diabetes may indicate the occurrence or aggravation of coronary heart disease, which may be of significance in the diagnosis and treatment of type 2 diabetes with coronary heart disease.