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目的 研究肺癌患者外周血单个核细胞（ＰＢＭＣｓ） 分泌ＩＬ－４（白细胞介素－４） 的水平，及根治手术对其影响。方法 采用酶联免疫方法测定了４０ 例肺癌手术前、１４ 例肺癌根治手术前后及３０ 例正常对照、１１ 例肺部良性疾病对照者ＩＬ－ ４ 的水平。结果 肺癌组分泌ＩＬ－４ 水平（７－９１８±５－０７１）ｎｇ／Ｌ低于正常对照组（１９－２９７ ±１０－６８５）ｎｇ／Ｌ（ Ｐ＜０－０１），亦低于肺部良性疾病组（１４－０３２±１１－２９７）ｎｇ／Ｌ（ Ｐ＜０－０５） 。根治手术后产生ＩＬ－ ４ 水平明显提高（ ｔ ＝２－２４４，Ｐ＜ ０－０５）。结论 检测ＰＢＭＣｓ 分泌ＩＬ－４ 水平对肺癌的诊断、疗效监测有重要的临床实际意义。
Objective To investigate the levels of IL-4 (interleukin-4) secreted by peripheral blood mononuclear cells (PBMCs) from patients with lung cancer and their effect on radical surgery. Methods The levels of IL-4 in 40 lung cancer patients, 14 lung cancer patients undergoing radical surgery, and 30 normal controls and 11 benign lung disease control subjects were determined by enzyme-linked immunosorbent assay. Results The level of IL-4 secreted by the lung cancer group (7-918±5-071)ng/L was lower than that of the normal control group (19-297±10-685)ng/L (P<0-01), which was also lower than that of the lungs. Benign disease group (14-032±11-297) ng/L (P<0-05). IL-4 levels increased significantly after radical surgery (t = 2-244, P < 0-05). Conclusion The detection of IL-4 levels secreted by PBMCs has important clinical practical significance in the diagnosis and monitoring of lung cancer.