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作者评价了长期小剂量环孢菌素(Cyclosporin,Cys)治疗银屑病的效果。 13例银屑病患有,男性5例、女性8例,年龄27～74岁。所有患者在使用Cys前停用局部给药治疗2周,停用全身性用药4周。采用银屑病区域和其严重标志评分法来评价药效。本组患者使用Cys12～25个月(平均18个月)。剂量为每日1～4mg/kg(平均2.8mg)。10例患者完成了此研究。研究结果显示,用药4周时,平均银屑病区域和严重标志分数减少了72%,研究结束时,减少了81%。用药过程中6例出现轻～中度高血压;3例经减少Cys剂量、3例经使用抗高血压药后高血压被控制。平均血肌酸
The authors evaluated the efficacy of long-term low-dose cyclosporin (Cys) in the treatment of psoriasis. 13 cases of psoriasis patients, 5 males and 8 females, aged 27 to 74 years. All patients discontinued topical treatment for 2 weeks prior to Cys and systemic treatment discontinued for 4 weeks. The psoriasis area and its severe marker score were used to assess efficacy. This group of patients using Cys12 ~ 25 months (average 18 months). The dose is daily 1 ~ 4mg / kg (average 2.8mg). Ten patients completed the study. Results showed that mean psoriasis area and severe marker scores decreased by 72% at 4 weeks of treatment and by 81% at the end of the study. 6 cases of mild to moderate hypertension in the course of medication; 3 cases to reduce the Cys dose, 3 cases were controlled by the use of antihypertensive drugs after high blood pressure. Average blood creatine