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目的:对氨溴索辅助治疗慢性阻塞性肺疾病急性加重期疗效进行观察和研究。方法:对本院呼吸内科95例copd急性加重期患者进行分组对照研究,观察组47例,给予氨溴索注射液,对照组48例,给予常规治疗,两组均给予吸氧、抗感染、平喘、纠正酸碱失衡、支气管解痉剂及全身或局部应用糖皮质激素等常规综合治疗。总疗程10d。观察两组患者治疗前后血气分析变化和疗效。结果:治疗组的显效率63.83%,总有效率89.36%,均高于对照组的43.75%和79.17%(p<0.05)。两组治疗后氧分压(pao2)、二氧化碳分压(paco2)比较差异有统计学意义(p<0.05)。结论:氨溴索治疗COPD急性加重期疗效确切,值得临床推广应用。
OBJECTIVE: To observe and study the efficacy of ambroxol in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods: A total of 95 patients with acute exacerbation of copd in our department of respiratory medicine were divided into control group and 47 patients in observation group. Ambroxol injection and control group were given routine treatment. Both groups were given oxygen, anti-infection, Anti-asthma, to correct acid-base imbalance, bronchial spasm agent and systemic or topical glucocorticoid and other conventional comprehensive treatment. The total course of treatment 10d. Blood gas analysis before and after treatment changes and efficacy were observed. Results: The effective rate of the treatment group was 63.83%, the total effective rate was 89.36%, which was higher than that of the control group (43.75% and 79.17%, p <0.05). After treatment, the oxygen partial pressure (pao2) and carbon dioxide partial pressure (paco2) were significantly different (p <0.05). Conclusion: Ambroxol treatment of acute exacerbation of COPD exact effect, worthy of clinical application.