慢性肝病患者骨软化和/或骨质疏松的危险性增加,虽然组织学研究包括用双四环素标记测定钙化作用和测定类骨质含量,骨软化并不象以前料想的那么常见。骨软化的机制被认为是维生素D缺乏。在胆汁郁积性疾病(如原发性胆硬化)中常见的骨质疏松的原因不肯定且毫无凝问是多因素的。在肝性骨营养不良患者,甚至在患严重骨疾病时血浆全钙和离子化钙水平同血浆磷酸盐值一样通常是正常的。很少对血浆碱性磷酸酶水平测定,因为一般情况下肝脏内碱性磷酸酶 Patients with chronic liver disease are at an increased risk of osteomalacia and / or osteoporosis. Although histological studies, including the use of tetracycline markers to measure calcification and osteoid-like content, osteomalacia is not as common as previously thought. The mechanism of osteomalacia is thought to be vitamin D deficiency. The reasons for osteoporosis, common in cholestatic disorders such as primary biliary cirrhosis, are multifactorial and unfrozen. In patients with hepatic osteodystrophy, plasma total calcium and ionized calcium levels, as well as plasma phosphate values, are usually normal, even in severe bone disorders. Alkaline phosphatase levels are seldom measured because, in general, intrahepatic alkaline phosphatase