本文报道,用GC测定人血浆中普萘洛尔(Ⅰ)、美托洛尔(Ⅱ)等,苯丁酮类药物不干扰。用甲基硅酮毛细管柱,保留时间:Ⅰ5.5 min, Ⅱ17 min,氟哌啶醇(Ⅲ) 19.5min,匹泮哌隆(Ⅳ)(内标)21.5 min,醋哌丁隆(Ⅴ)24.5 min,苯哌唑酮(Ⅵ)和氟哌利多(Ⅶ)29 min。用甲基-苯基硅酮毛细管柱,保留时间:Ⅱ4.5 min,莫哌隆(Ⅷ)8.5min,Ⅲ21 min,Ⅳ(内标)23.5 min,Ⅴ26.5 min,Ⅵ和Ⅶ31.8 min。各化合物在50～300 ng/ml浓度范围内,相关系数0.9～1.0,回收率80％～90％。最低检出浓度,火焰离 This article reports the determination of propranolol (Ⅰ) and metoprolol (Ⅱ) in human plasma by GC without the interference of phenylbutanone. Using methyl silicone capillary column, retention time: Ⅰ.5.5 min, Ⅱ17 min, haloperidol (Ⅲ) 19.5 min, Pirapapellone (Ⅳ) (internal standard) 21.5 min, 24.5 min, and then treated with dipivoxil (Ⅵ) and droperidol (Ⅶ) for 29 min. The retention time: Ⅱ 4.5 min, Ⅲ, min 21 min, Ⅳ (internal standard) 23.5 min, Ⅴ 26.5 min, Ⅵ and Ⅶ 31.8 min with methyl-phenyl silicone capillary column, . The concentration of each compound in the range of 50 ~ 300 ng / ml, the correlation coefficient of 0.9 to 1.0, the recovery rate of 80% to 90%. Minimum detectable concentration, flame away