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到热带国家疟疾流行区旅游者约有30％—50％发生腹泻。研究腹泻对氯喹和氯胍(Proguanil)吸收率的影响有助于确定患腹泻的旅游者服用预防疟疾药物剂量有无更改的必要。作者选4周内自疟区旅游归来的12例腹泻成人作实验组,另12例无腹泻成人作为对照组,两组对象于实验前一晚禁食,在排空小便后分别服用肠道渗透性的试验液50ml(含甘露醇5g和15ml含10g乳果糖(Lactulose)的0.5％氯仿水溶液),5min后服300mg氯喹和200mg氯胍。尔后收集6h
About 30% -50% of travelers to malaria-endemic areas in tropical countries develop diarrhea. Studying the impact of diarrhea on the absorption of chloroquine and Proguanil can help determine the need for any change in doses of medications used to prevent malaria among travelers with diarrhea. The authors selected 12 cases of diarrhea adults who returned from the malaria area within 4 weeks as experimental group and the other 12 cases of non-diarrhea adults as control group. The subjects in the two groups were fasted overnight before the experiment and were given intestinal permeability 50 ml of the test liquid (containing 5 g of mannitol and 15 ml of a 0.5% aqueous solution of chloroform containing 10 g of Lactulose) is added and after 5 min 300 mg of chloroquine and 200 mg of proguanil are taken. After collecting 6h