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目的 :整合素 (ｉｎｔｅｇｒｉｎｓ)是一类广泛存在于细胞表面的糖蛋白。在造血细胞的整合素由α和β两个亚基组成 ,参与细胞与胞外基质、细胞骨架的莲接 ,并通过酪氨酸和丝氨酸蛋白激酶系统介导细胞信息的传递。αｖβ5的过度表达与肿瘤转移及血管形成有关。αｖβ3也已证实与
AIM: Integrins are a group of glycoproteins that are found on the cell surface. Integrins in hematopoietic cells are composed of two subunits, alpha and beta, which are involved in cell-cell attachment to extracellular matrix and cytoskeleton, and mediate the transmission of cellular information through the tyrosine and serine protein kinase systems. Overexpression of αvβ5 is associated with tumor metastasis and angiogenesis. αvβ3 has also been confirmed with