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目的探讨来曲唑促排卵治疗对接受体外受精-胚胎移植(IVF-ET)助孕的不育症患者获卵、受精和妊娠结局的影响。方法选取济源市妇幼保健院妇产科2013年6月至2014年6月收治的90例不孕症患者为研究对象,按是否符合卵巢低反应(POR)标准将其分为对照组和观察组,每组45例。对照组皮下注射短效GnRH-a,月经开始后第3天行控制性促排卵,观察组口服来曲唑促排卵治疗。比较两组患者的治疗效果。结果两组未获卵率、获卵数、可移植胚胎数比较差异均有统计学意义(P<0.05),但受精率、卵裂率比较差异未见统计学意义(P>0.05);两组取消周期率、临床妊娠率/取卵周期比较差异均有统计学意义(P<0.05),但胚胎种植率、临床妊娠率/移植周期和流产率比较差异未见统计学意义(P>0.05)。结论来曲唑促排卵受精和卵裂情况较好,对子宫内膜无明显影响,适宜受精卵着床,适用于IVF-ET卵巢低反应患者。
Objective To investigate the effects of letrozole on ovulation, fertilization and pregnancy outcomes in infertile women receiving IVF-ET. Methods 90 cases of infertility patients who were admitted to Gynecology and Obstetrics Hospital of Jiyuan Maternal and Child Health Hospital from June 2013 to June 2014 were selected as research objects and divided into control group and observation group according to whether they meet the criteria of low ovarian response (POR) , 45 cases in each group. Control group subcutaneous injection of short-acting GnRH-a, the first three days after menstruation line control ovulation induction, the observation group oral letrozole ovulation therapy. The treatment effect of two groups of patients was compared. Results There were significant differences in the number of undereated eggs, the number of oocytes retrieved and the number of transplanted embryos in both groups (P <0.05), but there was no significant difference in fertilization rate and cleavage rate between the two groups (P> 0.05) There were significant differences in cycle rate, clinical pregnancy rate / ovulation cycle between the two groups (P <0.05), but there was no significant difference in embryo implantation rate, clinical pregnancy rate / graft cycle and abortion rate (P> 0.05 ). Conclusion Letrozole ovulation fertilization and cleavage better, no significant effect on the endometrium, suitable for fertilized egg implantation, suitable for IVF-ET patients with low ovarian response.