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The novel quatized hydroxypropyl cellulose-g-poly(THF-co-epichlorohydrin) graft copolymers,HPC-g-QCP(THF-co-ECH),have been successfully synthesized to combine the properties from hydrophilic hard HPC biomacromolecular backbone and hydrophobic flexible polyether branches.Firstly,the P(THF-co-ECH) living chains were synthesized by cationic ring-opening copolymerization of THF with ECH.Secondly,P(THF-co-ECH) living chains were grafted onto HPC backbone by reaction with-OH groups along HPC to produce HPC-g-P(THF-co-ECH) graft copolymers.Thirdly,the mentioned graft copolymers were quatized by reaction with tanyamine to generate functionalized HPC-g-QCP(THF-co-ECH).The HPC-g-QCP(THF-co-ECH) graft copolymers exhibited good antibacterial ability against S.aureus or E.coli bacteria.The ibuprofen (IBU)-loaded microparticles of HPC-g-(QC)P(THF-co-ECH) graft copolymers were prepared by electrospraying.The in vitro pH-responsive drug-release behavior of IBU reached up to 75％ of drug-loaded at pH =7A.This quatized graft copolymer was beneficial to solving the problems of a burst effect and fast release of HPC as drug carriers.