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目的探讨儿童血清25-羟基维生素D[25-(OH)D]水平与肥胖的关系。方法采用病例对照研究方法选择2012年1月-2014年1月在重庆南桐矿业有限责任公司总医院就诊的57名肥胖儿童及73名正常体质指数(BMI)儿童作为研究对象,收集人口学信息及临床资料。结果观察组儿童BMI、腰围及收缩压数值均高于对照组,两组比较,差异有统计学意义(均P=0.000)。观察组儿童血脂异常,其低密度脂蛋白胆固醇(LDL-C)高于对照组,而高密度脂蛋白胆固醇(HDL-C)低于对照组(P=0.000);观察组儿童存在胰岛素抵抗(P<0.000)。Spearman相关分析结果表明,血清25-(OH)D水平与BMI、腰围、收缩压、LDL-C、胰岛素呈负相关,与HDL-C呈正相关(均P=0.000)。结论重庆地区儿童群体血清25-(OH)D水平普遍低下,且血清25-(OH)D水平不足,显著增加肥胖发病风险。
Objective To investigate the relationship between serum 25-hydroxyvitamin D [25- (OH) D] and obesity in children. Methods A case-control study was conducted to select 57 obese children and 73 normal body mass index (BMI) children from January 2012 to January 2014 in the General Hospital of Nantong Mining Co., Ltd., Chongqing. The demographic information And clinical data. Results The BMI, waist circumference and systolic blood pressure in observation group were higher than those in control group. There was significant difference between the two groups (P = 0.000). The level of LDL-C in the observation group was higher than that in the control group, while the level of HDL-C in the observation group was lower than that in the control group (P = 0.000). Insulin resistance P <0.000). Spearman correlation analysis showed that serum 25- (OH) D level was negatively correlated with BMI, waist circumference, systolic blood pressure, LDL-C and insulin, and positively correlated with HDL-C (all P = 0.000). Conclusion The level of serum 25- (OH) D in Chongqing children is generally low, and the level of serum 25- (OH) D is not enough, which significantly increases the risk of obesity.