A first facile total synthesis of 12-hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one 9was accomplished via a strategy of AC→ABC. In the synthetic process, compound 5 wassynthesized through Reimer-Teimann reaction, followed by methylation, reduction, dehydration,addition to ethylene epoxide and chlorination. The target compound 9 was finally obtainedthrough the condensation of Grignard reagent of compound 5 with 6, followed by intramolecularcyclization, reduction and demethylation. A first facile total synthesis of 12-hydroxy-13-methylpodocarpa-9, 11, 13-trien-3-one via a strategy of AC → ABC. In the synthetic process, compound 5 wassynthesized through Reimer-Teimann reaction, followed by methylation, reduction, dehydration, addition to ethylene epoxide and chlorination. The target compound 9 was finally obtained through the condensation of Grignard reagent of compound 5 with 6, followed by intramolecularcyclization, reduction and demethylation.