原发性十二指肠癌是少见的,约占所有胃肠道恶性肿瘤的0.3%和小肠恶性肿瘤的25～45%。到1974年文献中仅报导694例,作者报导66例经组织病理学证实的十二指肠腺癌患者。患者的发病高峰在60～70岁间(年龄中位数为66岁),女/男为1.2/1(36:30)。常规的钡剂检查在46/66例患者中施行,68%作出了正确诊断,在检查中10%提示疑有某种程度的阻塞,22%认为完全正常。10/49例(20%)患者征剖腹探查或胆囊切除中意外地发现十二指肠肿瘤。17例患者(25%)生前未能诊断,直到死后才作出诊断。从首次就诊到作出正确诊断的平均时间为7.5月,43例患者(65%)<6 Primary duodenal cancer is rare, accounting for approximately 0.3% of all gastrointestinal malignancies and 25-45% of small intestinal malignancies. Only 694 cases were reported in the 1974 literature. The authors reported 66 patients with histologically confirmed duodenal adenocarcinoma. The peak incidence of patients was between 60 and 70 years old (median age was 66 years) and female/male was 1.2/1 (36:30). Routine tinctures were performed in 46/66 patients, 68% made the correct diagnosis, 10% indicated that some degree of blockage was suspected, and 22% considered completely normal. Unexpectedly, duodenal tumors were found in 10/49 (20%) patients undergoing exploratory laparotomy or cholecystectomy. Seventeen patients (25%) had not been diagnosed before their lifetime and did not make the diagnosis until after death. The average time from first consultation to correct diagnosis was 7.5 months, 43 patients (65%) <6