内皮素是一类多功能细胞因子,对神经内分泌,多种内脏细胞的生长与功能调节均有影响,另外尚具有免疫和致炎作用。作者就来自血管内皮的内皮素-1和来自内脏粘膜的内皮素-4对单核细胞产物的影响进行了研究。这些单核细胞产物包括肿瘤坏死因子(TNFα),IL-1β,IL-6,IL-8及粒细胞-巨噬细胞集落刺激因子(GM-CSF)。观察对象为健康成年男女志愿者,取其外 Endothelin is a kind of multifunctional cytokines, which have effects on neuroendocrine, growth and function regulation of many kinds of visceral cells. In addition, endothelin also has immune and proinflammatory effects. The authors studied the effects of endothelin-1 from the vascular endothelium and endothelin-4 from the visceral mucosa on mononuclear cell products. These monocyte products include tumor necrosis factor (TNFα), IL-1β, IL-6, IL-8 and granulocyte-macrophage colony stimulating factor (GM-CSF). Observe the target for healthy adult men and women volunteers, whichever is the exception