论文部分内容阅读
目的:观察与分析螺内酯治疗难治性高血压的有效性和安全性。方法:选取本院近2年门诊收治的52例难治性高血压患者作为研究对象。将他们随机分为观察组26例和对照组26例,观察组患者在基础治疗的基础上加用螺内酯治疗,20mg/天,对照组患者仅采用基础治疗的方式(即抗高血压治疗),对患者在治疗前和经过3周治疗后的血压进行检测,并且检测观察组患者在治疗前和治疗后的血钾水平。结果:观察组患者治疗后舒张压和收缩压与治疗前相比具有统计学意义,且在治疗前后其血钾都在正常的范围内。结论:在保证血钾稳定的情况下,难治性高血压患者在基础治疗的基础上(利尿药、钙离子拮抗药、ACE抑制剂)加用小剂量的螺内酯进行辅助治疗可取得良好的血压效果。
Objective: To observe and analyze the efficacy and safety of spironolactone in the treatment of refractory hypertension. Methods: Fifty-two patients with refractory hypertension admitted to our clinic in the past two years were selected as the study subjects. They were randomly divided into observation group (n = 26) and control group (n = 26). Patients in observation group were treated with spironolactone on the basis of basic treatment at 20mg / day. Patients in control group were treated only with basic treatment (antihypertensive treatment) Blood pressure was measured before treatment and after 3 weeks of treatment, and potassium levels in the observation group before and after treatment were measured. Results: The diastolic blood pressure and systolic blood pressure after treatment in the observation group were statistically significant compared with those before treatment, and their serum potassium was within the normal range before and after treatment. Conclusion: In the condition of stable serum potassium, patients with refractory hypertension can get good blood pressure on the basis of basic treatment (diuretics, calcium antagonists and ACE inhibitors) and small dose of spironolactone for adjuvant therapy effect.