目的探析性早熟儿童病因及与性别、年龄相关性。方法 435例性早熟儿童临床资料行回顾性分析,分析患儿一般临床资料、发病原因,并对所得数据行统计学分析。结果性早熟患儿中女性多于男性;随着年龄增长性早熟发病率逐渐升高。儿童性早熟病因单纯乳房早发育最常见占61.38%;中枢性性早熟中特发性性早熟和原发性甲状腺功能减退症较为多见,分别占9.66%和5.52%;外周性性早熟患儿中卵巢囊肿最常见,占11.49%。结论儿童性早熟发病原因较多,女性明显多于男性,由器质性发病较为少见,随着年龄增长发病率可逐步升高,临床中对有第二性征早期发育儿童进行早期诊断并治疗,以保障儿童健康成长。 Objective To investigate the etiology and sex and age-related relationship of precocious children. Methods The clinical data of 435 cases of precocious puberty children were retrospectively analyzed. The general clinical data and the causes of the disease were analyzed. The data were statistically analyzed. The results of precocious puberty in women than in men; with age, the incidence of precocious puberty gradually increased. Early childhood maternal etiology of simple breast early development accounted for the most common 61.38%; Central precocious puberty and idiopathic hypothyroidism more common, accounting for 9.66% and 5.52% respectively; children with peripheral precocity Ovarian cysts in the most common, accounting for 11.49%. Conclusions There are many causes of precocious puberty in children, and there are more women than men. The incidence of organic diseases is rare, and the incidence of childhood precocious puberty can be gradually increased. Early diagnosis and treatment of children with early sexual traits , To protect the healthy growth of children.