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目的:观察止喘润肺汤联合氟替卡松沙美特罗气雾剂改善职业性哮喘患者肺功能及临床疗效的情况。方法:选择职业性哮喘患者90例,随机分为治疗组(45例)和对照组(45例),对照组给予氟替卡松沙美特罗气雾剂治疗,治疗组在对照组基础上加用止喘润肺汤,14天后观察两组患者治疗前后临床疗效及肺功能等指标的变化情况。结果:(1)两组治疗后,喘息、哮鸣等症状及肺部听诊体征均有不同程度的改善,但治疗组优于对照组。(2)治疗组和对照组治疗前后肺功能值比较,大部分肺功能参数差异有统计学意义(P<0.05)。对照组用力肺活量(FVC)、最大呼气中段流速(MMEF)、最大用力呼气流速(PEF)、第1秒用力呼气容量(FEV1)、25%和50%肺活量时的最大呼气流速(FEF25、FEF50)显著低于治疗组。结论:止喘润肺汤联合氟替卡松沙美特罗气雾剂治疗职业性哮喘可显著改善职业性哮喘患者的临床疗效和肺功能参数。
Objective: To observe the effect of Zhichuan Runfei decoction combined with fluticasone salmeterol aerosol on pulmonary function and clinical efficacy in patients with occupational asthma. Methods: Ninety patients with occupational asthma were randomly divided into treatment group (45 cases) and control group (45 cases). The control group was treated with fluticasone salmeterol aerosol. The treatment group was given asthma treatment on the basis of the control group Runfei Decoction, 14 days after treatment, the clinical efficacy and changes in lung function and other indicators were observed. Results: (1) After treatment, wheezing, wheezing and other signs of lung auscultation have different degrees of improvement, but the treatment group is better than the control group. (2) The lung function of the treatment group and the control group before and after treatment, most of the lung function parameters were statistically significant (P <0.05). FVC, MMEF, PEF, FEV 1, and maximal expiratory flow at 25% and 50% of vital capacity (FVC, FEF25, FEF50) was significantly lower than the treatment group. Conclusion: Zhichuan Runfei decoction combined with fluticasone salmeterol aerosol treatment of occupational asthma can significantly improve the clinical efficacy and pulmonary function parameters of patients with occupational asthma.