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目的 探讨细胞周期负性调控因子p2 7kip1,视网膜母细胞瘤 (Rb)基因蛋白和增殖细胞核抗原 (PC NA)在胰腺癌发生、发展中的作用。方法 应用免疫组织化学技术 (SP法 ) ,对 32例胰腺癌及癌旁组织中p2 7kip1、Rb蛋白和PCNA表达进行检测。结果 p2 7kip1蛋白阳性表达率在胰腺癌组织中为 5 6 2 5 %,显著低于癌旁胰腺组织 (84 37%) (P <0 0 5 ) ,并与胰腺癌组织分化程度及淋巴结转移相关 (P <0 0 5 ) ;Rb基因蛋白阳性表达率在胰腺癌组织中为 5 0 0 0 %,显著低于癌旁胰腺组织 (78 13%) (P <0 0 5 ) ;PCNA阳性表达率在胰腺癌组织中为 71 87%,显著高于癌旁胰腺组织 (4 3 75 %) (P <0 0 5 ) ,并与胰腺癌组织分化程度和淋巴结转移均相关(P <0 .0 5 )。结论 p2 7kip1、Rb基因蛋白和PCNA与胰腺癌发生、发展密切相关。
Objective To investigate the roles of cell cycle negative regulatory factor (p2 7kip1), retinoblastoma (Rb) gene and proliferating cell nuclear antigen (PCNA) in the pathogenesis of pancreatic cancer. Methods The expression of p27kip1, Rb protein and PCNA in 32 cases of pancreatic cancer and its adjacent tissues were detected by immunohistochemistry (SP method). Results The positive rate of p2 7kip1 protein in pancreatic carcinoma was 56.2%, significantly lower than that in adjacent pancreatic tissues (84.37%) (P <0.05), which was correlated with the degree of differentiation and lymph node metastasis (P <0.05). The positive expression rate of Rb protein was 100% in pancreatic cancer tissues, which was significantly lower than that in adjacent pancreatic tissues (78.13%) (P <0 05) It was 71 87% in pancreatic cancer tissues, which was significantly higher than that in adjacent pancreatic tissues (43 75%) (P 0 05), which was correlated with the degree of pancreatic cancer differentiation and lymph node metastasis (P 0.05) ). Conclusion The expressions of p2 7kip1, Rb protein and PCNA are closely related to the occurrence and development of pancreatic cancer.